We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Minimal Atrophy of the Entorhinal Cortex and Hippocampus: Progression of Cognitive Impairment.
- Authors
Varon, Daniel; Loewenstein, David A.; Potter, Elizabeth; Greig, Maria T.; Agron, Joscelyn; Qian Shen; Weizhao Zhao; Ramirez, Maria Celeste; Santos, Isael; Barker, Warren; Potter, Huntington; Duara, Ranjan
- Abstract
Background: In Alzheimer's disease, neurodegenerative atrophy progresses from the entorhinal cortex (ERC) to the hippocampus (HP), limbic system and neocortex. The significance of very mild atrophy of the ERC and HP on MRI scans among elderly subjects is unknown. Methods: A validated visual rating system on coronal MRI scans was used to identify no atrophy of the HP or ERC (HP0; ERC0), or minimal atrophy of the HP or ERC (HPma; ERCma), among 414 participants. Subjects fell into the following groups: (1) ERC0/HP0, (2) ERCma/HP0, (3) ERC0/HPma, and (4) ERCma/HPma. HP volume was independently measured using volumetric methods. Results: In comparison to ERC0/HP0 subjects, those with ERC0/HPma had impairment on 1 memory test, ERCma/HP0 subjects had impairment on 2 memory tests and the Mini Mental State Examination (MMSE), while ERCma/HPma subjects had impairment on 3 memory tests, the MMSE and Clinical Dementia Rating. Progression rates of cognitive and functional impairment were significantly greater among subjects with ERCma. Conclusion: Minimal atrophy of the ERC results in greater impairment than minimal atrophy of the HP, and the combination is additive when measured by cognitive and functional tests. Rates of progression to greater impairment were higher among ERCma subjects. Copyright © 2011 S. Karger AG, Basel
- Subjects
BRAIN anatomy; COGNITION disorders diagnosis; ANALYSIS of variance; BRAIN; CHI-squared test; HIPPOCAMPUS (Brain); MAGNETIC resonance imaging; RESEARCH funding; STATISTICS; DATA analysis; DISEASE progression
- Publication
Dementia & Geriatric Cognitive Disorders, 2011, Vol 31, Issue 4, p276
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000324711