We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sympathetic neurogenic Ca<sup>2+</sup> signalling in rat arteries: ATP, noradrenaline and neuropeptide Y.
- Authors
Wier, W. Gil; Wei-jin Zang; Lamont, Christine; Raina, Hema
- Abstract
The sympathetic nervous system (SNS) plays an essential role in the control of total peripheral vascular resistance by controlling the contraction of small arteries. The SNS also exerts long-term trophic influences in health and disease; SNS hyperactivity accompanies most forms of human essential hypertension, obesity and heart failure. At their junctions with smooth muscle cells, the peri-arterial sympathetic nerves release ATP, noradrenaline (NA) and neuropeptide Y (NPY) onto smooth muscle cells. Confocal Ca2+ imaging studies reveal that ATP and NA each produce unique types of postjunctional Ca2+ signals and consequent smooth muscle cell contractions. Neurally released ATP activates postjunctional P2X1 receptors to produce local, non-propagating Ca2+ transients, termed ‘junctional Ca2+ transients’, or ‘jCaTs’. Neurally released NA binds to α1-adrenoceptors and can activate Ca2+ waves or more uniform global changes in [Ca2+]. Neurally released NPY does not appear to produce Ca2+ transients directly, but significantly modulates NA-induced Ca2+ signalling. The neural release of ATP and NA, as judged by postjunctional Ca2+ signals, electrical recording of excitatory junction potentials and carbon fibre amperometry to measure NA, varies markedly with the pattern of nerve activity. This probably reflects both pre- and postjunctional mechanisms, which are not yet fully understood. These phenomena, together with different temporal patterns of sympathetic nerve activity in different regional circulations, are probably an important mechanistic basis of the important selective regulation of regional vascular resistance and blood flow by the sympathetic nervous system.
- Subjects
SYMPATHETIC nervous system; ARTERIES; HYPERTENSION; OBESITY; HEART failure; SMOOTH muscle; MUSCLE cells; NEUROPEPTIDES
- Publication
Experimental Physiology, 2009, Vol 94, Issue 1, p31
- ISSN
0958-0670
- Publication type
Article
- DOI
10.1113/expphysiol.2008.043638