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- Title
Immunological and Clinical Characteristics of Systemic Lupus Erythematosus: A Series from Morocco.
- Authors
Zian, Zeineb; Maamar, Mouna; Aouni, Mohamed El; Barakat, Amina; Naima Ghailani Nourouti; El Aouad, Rajae; Arji, Naima; Bennani Mechita, Mohcine
- Abstract
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with a high female predominance. To date, studies about SLE in Morocco are few. This retrospective study describes the clinical and immunological features in a series of 50 SLE Moroccan patients in University Hospital Center of Rabat, Morocco, between December 2011 and December 2013. All patients were screened for antinuclear antibodies (ANA) and anti-DNA antibodies by indirect immunofluorescence, followed by identification of anti-extractable nuclear antigen antibodies by ELISA. The female to male ratio was 6.1:1. Mean age was 31.72 years. The main clinical manifestations were arthritis (82%), mucocutaneous manifestations (80%), renal manifestations (50%), and hematological features (46%). Of the mucocutaneous features, the highest frequencies were observed in the malar rash (68%) and photosensitivity (60%). Of the hematological features, lymphopenia was most frequently observed in 30% of patients, followed by hemolytic anemia in 16% and leucopenia and thrombocytopenia in 8%. Central nervous system was involved in 10%. ANA were found in 88%, anti-DNA antibodies in 56%, and anti-Sm antibodies in 50%. Anti-SSA, anti-SSB, anti-Sm/RNP, and anti-Scl70 antibodies were detected in 38%, 10%, 48%, and 8%, respectively. Our data show that, in our patients, the main clinical and immunological features of SLE remain comparable to patients from other Arab countries.
- Subjects
MOROCCO; AUTOANTIBODY analysis; ACADEMIC medical centers; ARTHRITIS; CENTRAL nervous system; ENZYME-linked immunosorbent assay; EXANTHEMA; FLUORESCENT antibody technique; HEMOLYTIC anemia; KIDNEYS; LEUCOPENIA; PHOTOSENSITIVITY disorders; SYSTEMIC lupus erythematosus; THROMBOCYTOPENIA; RETROSPECTIVE studies; LYMPHOPENIA; DESCRIPTIVE statistics
- Publication
BioMed Research International, 2018, Vol 2018, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2018/3139404