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- Title
Body weight gain induced by atypical antipsychotics: an extension of the monocygotic twin and sib pair study.
- Authors
Gebhardt, S.; Theisen, F. M.; Haberhausen, M.; Heinzel-Gutenbrunner, M.; Wehmeier, P. M.; Krieg, J.-C.; Kühnau, W.; Schmidtke, J.; Remschmidt, H.; Hebebrand, J.
- Abstract
Background and objective: In our original study based on five monozygotic twin pairs and seven same-sex sib pairs, we previously showed that genetic factors contribute to body weight gain induced by the atypical antipsychotic clozapine. We aim to study this further by including patients treated with the atypical antipsychotics olanzapine or risperidone as well as opposite-sex sib pairs. Methods: Twin and sib pairs were identified by a telephone screening. Measured data on weight and other clinical variables were obtained cross-sectionally and retospectively from medical records. In seven monozygotic twin pairs and 12 sib pairs (total number of patients treated: n = 38, mean age 29·5 ± 9·5, range 13·7–54·3 years), the similarity in BMI (kg/m2) change under these atypical antipsychotics (atypical ΔBMI) and upon additional inclusion of BMI change under prior antipsychotic medication (total ΔBMI) was explored. Results: For total ΔBMI we found greater similarity in antipsychotic-induced BMI change in MZ twin pairs than in sib pairs (intrapair difference) with a heritability of h2 = 0·6, but not for atypical ΔBMI, possibly because of a genetically influenced weight plateau achieved under antipsychotic medication. Conclusion: The results of the present and our previous report suggest a contribution of genetic factors in antipsychotic-induced weight gain of 60–80%.
- Subjects
ANTIPSYCHOTIC agents; WEIGHT gain; DRUG side effects; OLANZAPINE; RISPERIDONE; TWIN studies; GENETICS
- Publication
Journal of Clinical Pharmacy & Therapeutics, 2010, Vol 35, Issue 2, p207
- ISSN
0269-4727
- Publication type
Article
- DOI
10.1111/j.1365-2710.2009.01084.x