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- Title
MICROWAVE ASSISTED SYNTHESIS OF SOME 2-[(SUBSTITUTED BENZYLIDENE) IMINO]-3-(N-CYCLOHEXL CARBOXAMIDO)-4, 5- DI SUBSTITUTED THIOPHENES.
- Authors
Parmesh, Rekha; P., Lohitha; J., Saravanan
- Abstract
In this present work, a series of new 2-[(substituted benzylidene) imino]-3-(N-cyclohexl carboxamido)-4,5-di substituted thiophenes were synthesized in a multi step method and its structure has been elucidated by elemental analysis and spectral tools. In the first step Ncyclohexyl cyano acetamide MSR-5 was synthesized by the condensation of Cyclohexylamine and Ethyl cyano acetate. Reaction of compound MSR-5 with methylenic ketone using ammonium acetate and glacial acetic acid as an acidic catalyst was carried out by refluxation in benzene for 8hrs by employing Dean Stark apparatus afforded 2-Cyano -2- (alkylidene)-N-cyclohexyl carboxamides [I]. Compound [I] represents the important key intermediate from which all the new target polysubstituted thiophenes were synthesized thus compound [2] was introduced in reaction by dissolving in alcohol react with elemental sulfur in the presence of basic catalyst, diethyl amine in ethanol to form 2-amino-3-(cyclohexyl carboxamido)-4,5-di substituted thiophenes MSR-11 & 12. In the final step a new series of compounds were synthesized from 2- amino-3-N-cyclohexyl carboxamido-4,5-disubstituted thiophenes (MSR-11&12) by heating in a microwave oven with various substituted aromatic aldehydes in isopropyl alcohol with glacial acetic acid as a catalyst to yield 2-[(substituted benzylidene) imino]-3-(N-cyclohexl carboxamido)- 4,5-disustituted thiophenes MSR-11a-11k & MSR-12a-12k.
- Subjects
THIOPHENES; CHEMICAL synthesis; CARBOXAMIDES; BENZYLIDENE compounds
- Publication
International Journal of Pharmaceutical, Chemical & Biological Sciences, 2015, Vol 5, Issue 3, p649
- ISSN
2249-9504
- Publication type
Article