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- Title
Association of High Plasma Levels of Serpin E1, IGFBP2, and CCL5 With Refractory Epilepsy in Children by Cytokine Profiling.
- Authors
Du, Yaning; Xiao, Xiao; You, Hai-Zhen; Hou, Zhao-yuan; Yang, Xiao-Dong; Wang, Jiwen; Tang, Jihong; Wang, Yingyan
- Abstract
Inflammatory cytokines participate in the pathology of epilepsy and the development of drug resistance. In this study, we combined a cytokine array and enzyme-linked immunosorbent assay to identify new cytokines in the plasma from children on early stage of the onset of epilepsy (EOE) and children with drug-resistant epilepsy (DRE). Compared with healthy controls, a broad up-regulation of cytokines was observed in patients with EOE, and many of the cytokines were not previously reported. In patients with DRE, most of these up-regulated cytokines maintained at relatively low levels close to those in controls; only a few of them, including CCL5, Serpin E1, and IGFBP2, remained at high levels. The dramatic difference in cytokine profile could be a strong clue for the incidence of DRE, and DRE-associated cytokines appeared to have the potential to be new biomarkers for epilepsy prognosis and therapeutic targets.
- Subjects
CHEMOKINES; PEARSON correlation (Statistics); T-test (Statistics); RECEIVER operating characteristic curves; RESEARCH funding; ENZYME-linked immunosorbent assay; LOGISTIC regression analysis; DESCRIPTIVE statistics; CHI-squared test; BLOOD coagulation factors; LONGITUDINAL method; ODDS ratio; CYTOKINES; CONFIDENCE intervals; CONNECTIVE tissue growth factor; CHILDHOOD epilepsy; DRUG resistance
- Publication
Clinical Pediatrics, 2024, Vol 63, Issue 7, p953
- ISSN
0009-9228
- Publication type
Article
- DOI
10.1177/00099228231201245