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- Title
Anticancer Activity of Graphene Oxide/5-FU on CT26 dsRED Adenocarcinoma Cell Line.
- Authors
AFARIDEH, BEHROOZ; RAJABIBAZL, MASOUMEH; OMIDI, MEISAM; YAGHMAEE, BAHRAM; RAHIMPOUR, AZAM; KHODABAKHSHI, REZA; SARVARIAN, SAEEIDEH
- Abstract
Cancer is one of the greatest health challenges in the world. Every year, many people die because of cancer. Chemotherapy is one of the treatment options in cancer disease. Fluorouracil) (5-FU) is one of the chemotherapy drugs, but it has relatively low toxic effect on tumor cells when it is used on free form, which also results in its poor efficacy. GO (graphene oxide) has a singleatomic layer and has several functional groups such as epoxide, carbonyl, carboxyl and hydroxyl which makes it a suitable carrier for drug loading. In the present study, we loaded 5-FU on GO nano-carrier to produce GO/5-FU, and characterized it by FT-IR. CT26 dsRED adenocarcinoma cell line was treated with GO/5-FU, free 5-FU, GO, and PBS (Phosphate buffer saline). The results showed significant inhibition of the CT26 dsRED cells using GO/5-FU compared to free 5-FU (P<0.05). Therefore, loaded 5-FU on GO (GO/5-FU) could be a new approach for optimization of 5-FU tumor cytotoxicity.
- Subjects
ANTINEOPLASTIC agents; GRAPHENE oxide; CELL lines; CANCER treatment; FOURIER transform infrared spectroscopy
- Publication
Oriental Journal of Chemistry, 2018, Vol 34, Issue 4, p2002
- ISSN
0970-020X
- Publication type
Article
- DOI
10.13005/ojc/3404038