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- Title
Effects of egonol that isolated from seeds of Styrax officinalis (L.) on lipid peroxidation and antioxidant defense system in human erythrocytes.
- Authors
Şahin-Bölükbaşı, Serap; Öztürk, Safiye Emirdağ; Anıl, Hüseyin; Siliğ, Yavuz
- Abstract
Objective: The aim of the present study was to investigate the effects on antioxidant defense system in human erythrocytes exposed to egonol that isolated from seeds of Styrax officinalis L. Method: A solution of Egonol was added so that final concentrations of Egonol were 0.2, 0.4, 0.6, 0.8, and 1 mg/ml and erythrocyte pellets were incubated for 15 minutes. Malondialdehyde (MDA) level, activities of glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST) glutathione were determined in hemolysis of human erythrocytes. Results: Activities of SOD and GST were markedly increased in erythrocyte of human blood compared to the control group (p<0.05) in all concentrations of egonol. This increase also dosedependent manner. The activities of SOD and GST enzymes were increased 30% and 70%, respectively, in 1 mg/ml egonol concentration. There were no statistically significant alterations in GPx and CAT enzyme activities. In addition, MDA level that is an indicator of lipid peroxidation was not found to be increased significantly. Conclusion: Those results revealed that egonol has no effect of enhancing free radical formation in erythrocyte thus also causes no increase lipid peroxidation was observed. It was observed that, egonol was increased SOD and GST enzymes activities and free radicals were disappeared by the antioxidant defense system so erythrocytes were preserved from the lipid peroxidation.
- Subjects
CATALASE; ANTIOXIDANTS; GLUTATHIONE transferase; GLUTATHIONE peroxidase; LIPID peroxidation (Biology); OXYGEN in the body
- Publication
Cumhuriyet Medical Journal, 2016, Vol 38, Issue 3, p168
- ISSN
1300-1957
- Publication type
Article
- DOI
10.7197/cmj.v38i3.5000199108