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- Title
Chemotherapy with Mitomycin-C and Cyclophosphamide Adjuvant to Surgery for Breast Cancer.
- Authors
YOSHIDA, MINORU; MURAI, HIROSHI; MIURA, SHIGETO
- Abstract
The effect of adjuvant chemotherapy on breast cancer was studied in two trials. In the first, mitomycin-C was administered intravenously to 203 patients and cyclophosphamide intravenously or orally to 72 patients, within four weeks after radical mastectomy. The results were evaluated by compairing the recurrence-free rates of these patients with those of 556 patients who received surgery alone.The effect of postsurgical adjuvant chemotherapy on the recurrence-free rate was statistically significantly better than that of surgery alone when one or two axillary lymph nodes were involved in metastasis, possibly because of the suppressive effect of chemotherapy on the establishment of hematogeneous metastases. With no or three to seven metastases, the recurrence-free rate for patients receiving surgical treatment combined with adjuvant chemotherapy was higher than that for those with surgery alone, but the difference was not statistically significant. In advanced cases having eight or more axillary lymph node metastases, chemotherapy appeared significantly to reduce the recurrence- free rate compared with surgery alone. This is possibly attributable to deterioration in host immunity caused by chemotherapy being administered immediately after surgery and affecting the host's defense mechanisms.In the second trial, which is still in progress, oral cyclophosphamide was administered to 172 patients, 150 mg daily, for 34 days from the seventh day after surgery. When compared with 179 patients having surgery alone, this chemotherapy increased the four-year recurrence-free rate in patients with no axillary lymph node metastases and the two-year recurrence-free rate in patients with eight or more axillary lymph node metastases.
- Publication
Japanese Journal of Clinical Oncology, 1979, Vol 9, Issue 1, p27
- ISSN
0368-2811
- Publication type
Article