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- Title
Multilevel neurium-mimetic individualized graft via additive manufacturing for efficient tissue repair.
- Authors
Kong, Lingchi; Gao, Xin; Yao, Xiangyun; Xie, Haijiao; Kang, Qinglin; Sun, Wei; You, Zhengwei; Qian, Yun; Fan, Cunyi
- Abstract
Complicated peripheral nerve injuries or defects, especially at branching sites, remain a prominent clinical challenge after the application of different treatment strategies. Current nerve grafts fail to match the expected shape and size for delicate and precise branched nerve repair on a case-by-case basis, and there is a lack of geometrical and microscale regenerative navigation. In this study, we develop a sugar painting-inspired individualized multilevel epi-/peri-/endoneurium-mimetic device (SpinMed) to customize natural cues, featuring a selectively protective outer sheath and an instructive core, to support rapid vascular reconstruction and consequent efficient neurite extension along the defect area. The biomimetic perineurium dictates host-guest crosslinking in which new vessels secrete multimerin 1 binding to the fibroin filler surface as an anchor, contributing to the biological endoneurium that promotes Schwann cell homing and remyelination. SpinMed implantation into rat sciatic nerve defects yields a satisfactory outcome in terms of structural reconstruction, with sensory and locomotive function restoration. We further customize SpinMed grafts based on anatomy and digital imaging, achieving rapid repair of the nerve trunk and branches superior to that achieved by autografts and decellularized grafts in a specific beagle nerve defect model, with reliable biosafety. Overall, this intelligent art-inspired biomimetic design offers a facile way to customize sophisticated high-performance nerve grafts and holds great potential for application in translational regenerative medicine. Nerve grafts often fail to match the expected shape and size for branched nerve repair. Here, the authors fabricate a sugar painting-inspired individualized multilevel epi-/peri-/endoneurium-mimetic device to achieve efficient regeneration of neural fibers.
- Subjects
PERIPHERAL nerve injuries; NERVE grafting; BIOMIMETICS; SCIATIC nerve; SCHWANN cells
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-49980-w