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- Title
C8ORF88: A Novel eIF4E-Binding Protein.
- Authors
Pugsley, Lauren; Naineni, Sai Kiran; Amiri, Mehdi; Yanagiya, Akiko; Cencic, Regina; Sonenberg, Nahum; Pelletier, Jerry
- Abstract
Translation initiation in eukaryotes is regulated at several steps, one of which involves the availability of the cap binding protein to participate in cap-dependent protein synthesis. Binding of eIF4E to translational repressors (eIF4E-binding proteins [4E-BPs]) suppresses translation and is used by cells to link extra- and intracellular cues to protein synthetic rates. The best studied of these interactions involves repression of translation by 4E-BP1 upon inhibition of the PI3K/mTOR signaling pathway. Herein, we characterize a novel 4E-BP, C8ORF88, whose expression is predominantly restricted to early spermatids. C8ORF88:eIF4E interaction is dependent on the canonical eIF4E binding motif (4E-BM) present in other 4E-BPs. Whereas 4E-BP1:eIF4E interaction is dependent on the phosphorylation of 4E-BP1, these sites are not conserved in C8ORF88 indicating a different mode of regulation.
- Subjects
SYNTHETIC proteins; CAPPING proteins; PROTEIN synthesis; CARRIER proteins; GENE expression
- Publication
Genes, 2023, Vol 14, Issue 11, p2076
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes14112076