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- Title
STUDY OF INCIDENCE, OUTCOME AND SIDE-EFFECT PROFILE OF INH MONORESISTANT TB TREATED WITH H MONO POLY DR REGIMEN.
- Authors
APARNA, VARIKUTI; KISSINGER, KOLA VIJAYA; ARUMUGAM, BHARGAVI; ARUNA, GORTHI
- Abstract
BACKGROUND - INH is an important first line Anti TB drug and unexpectedly, Mono resistance to INH has been found to be as high as 17.3% in India as per the India TB Report, 2023. This reduces treatment success rates and increases incidence of MDR-TB. The regimen used in these patients as per guidelines is 6LRZE (6 months of Levofloxacin, Rifamycin, Ethambutol and Pyrazinamide) AIM AND OBJECTIVE -To study the incidence, outcome and side effect profile of INH mono resistant TB when treated with H Mono Poly DR Regimen and to study the side effects of long term usage of Levofloxacin and Pyrazinamide. METHODOLOGY- 78 INH Mono resistant patients were diagnosed at the Designated Microscopy centre attached to the Respiratory Medicine OP, ACSR Govt. Medical College between 1st January 2023 and 1st July 2023 (6 months) and H Mono Poly DR regimen started. RESULTS: Out of the 78 INH MONO resistant patients, 30% belonged to 41-50 year age group (23 patients). 75% were males (57 patients), 10% developed side effects (8 patients) and about 23 % had comorbidities (18 patients). At the end of 6 months, 88.5% were declared cured (69 pts) and the Treatment Failure rate was 6.41% (5 patients). 3 deaths due to unrelated causes occurred during treatment
- Subjects
INDIA; TUBERCULOSIS; DIRECTLY observed therapy; TREATMENT failure; MEDICAL schools; AGE groups; RIFAMYCINS
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 3, p1141
- ISSN
0975-3583
- Publication type
Article