We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in Ovariectomized Rats and Bone Marrow Mesenchymal Stem Cells.
- Authors
Xia, Bingke; Dai, Xuan; Shi, Hanfen; Yin, Jiyuan; Xu, Tianshu; Liu, Tianyuan; Yue, Gaiyue; Guo, Haochen; Liang, Ruiqiong; Liu, Yage; Gao, Junfeng; Wang, Xinxiang; Chen, Xiaofei; Tang, Jinfa; Wang, Lili; Zhu, Ruyuan; Zhang, Dongwei
- Abstract
Recent interest in preventing the development of osteoporosis has focused on the regulation of redox homeostasis. However, the action of lycopene (LYC), a strong natural antioxidant compound, on osteoporotic bone loss remains largely unknown. Here, we show that oral administration of LYC to OVX rats for 12 weeks reduced body weight gain, improved lipid metabolism, and preserved bone quality. In addition, LYC treatment inhibited ROS overgeneration in serum and bone marrow in OVX rats, and in BMSCs upon H2O2 stimulation, leading to inhibiting adipogenesis and promoting osteogenesis during bone remodeling. At the molecular level, LYC improved bone quality via an increase in the expressions of FoxO1 and Runx2 and a decrease in the expressions of PPARγ and C/EBPα in OVX rats and BMSCs. Collectively, these findings suggest that LYC attenuates osteoporotic bone loss through promoting osteogenesis and inhibiting adipogenesis via regulation of the FoxO1/PPARγ pathway driven by oxidative stress, presenting a novel strategy for osteoporosis management.
- Subjects
OSTEOPOROSIS prevention; LIPID metabolism; PROTEINS; BONE marrow; RESEARCH funding; BONE growth; MESENCHYMAL stem cells; BODY weight; LIPIDS; CELLULAR signal transduction; DESCRIPTIVE statistics; ANIMAL experimentation; CELL differentiation; PEROXISOME proliferator-activated receptors; LYCOPENE; OVARIECTOMY
- Publication
Nutrients, 2024, Vol 16, Issue 10, p1443
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16101443