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- Title
Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases.
- Authors
Latacz, Maria; Snarska, Jadwiga; Kostyra, Elżbieta; Fiedorowicz, Ewa; Savelkoul, Huub F. J.; Grzybowski, Roman; Cieślińska, Anna
- Abstract
Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis. Modern literature lacks complete information on polymorphisms in CYP27B1, the only enzyme capable of vitamin D activation. This review presents gathered data that relate to genetic variants in CYP27B1 gene in correlation to multiple diseases, mostly concerning colorectal, prostate, breast, lung, and pancreatic cancers, as well as on other pathologies, such as non-Hodgkin's lymphoma, oral lichen planus, or multiple sclerosis.
- Subjects
CHRONIC disease risk factors; LYMPHOMA risk factors; MULTIPLE sclerosis risk factors; TUMOR risk factors; BREAST tumor risk factors; COLON tumors; GENETIC polymorphisms; LUNG tumors; OXIDOREDUCTASES; PANCREATIC tumors; PROSTATE tumors; RECTUM tumors; RISK assessment; VITAMIN D; ORAL lichen planus; DISEASE risk factors
- Publication
Nutrients, 2020, Vol 12, Issue 3, p801
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12030801