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- Title
SOX2 and NANOG expressions in glioblastoma multiforme.
- Authors
Tanrıöver, Gamze; Yıldırım, Sendegül; Ertosun, Mustafa Gökhan
- Abstract
Objective: Glioblastoma multiforme (GBM) is the most common malignant brain tumor in the human central nervous system. There is compelling evidence that brain tumors, particularly GBM, harbor a population of cancer stem cells (CSCs). These CSCs can undergo self-renewal, initiate tumors and they are resistant to therapy. It has been shown that CSCs within GBM characterized by the expression of the CSC markers such as SOX2 and NANOG. Previous studies have suggested that the overexpression or gene amplification of SOX2 and NANOG are putatively contributing to cellular invasion in tumors of neural and neural crest origin, including glioma. Even though little is known about the molecular mechanisms involved in GBM pathogenesis, the discovery of CSC has shown that the presence of CSC is correlated with the aggressiveness of gliomas. We hypothesized to identify SOX2 and NANOG as CSC markers in GBM. Therefore, we aimed to evaluate the SOX2 and NANOG expressions immunohistologically in GBM and normal brain tissues. Methods: With the approval of Akdeniz University Medical Faculty Clinical Research Ethics Committee; GBM samples were obtained from two (n=2) newly diagnosed patients who had not received GBM treatment previously and underwent resection at the Akdeniz University. For comparison, brain tissues of two patients who underwent partial brain resection due to trauma were used. Tissues immunohistochemically stained for the SOX2, NANOG. Results: Our study was demonstrated that the expression patterns of SOX2, NANOG proteins were clearly identified in tumor cells in GBM compared with normal brain tissues. Conclusion: Overexpression of SOX2 and NANOG correlates with the tumor progression in GBM. However, it is still not clear whether SOX2 and NANOG are critical for GBM prognosis. Our study was performed in a small number of patients for research but future studies are required for the examination of CSC specific markers in GBM tissues.
- Subjects
CANCER stem cells; GLIOBLASTOMA multiforme; CENTRAL nervous system tumors; BRAIN tumors; GENETIC overexpression; NEURAL crest
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2019, Vol 13, Issue S1, pS70
- ISSN
1307-8798
- Publication type
Article