We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of chronic irisin administration on body weight and reproductive organ weights in rats.
- Authors
Canpolat, Sinan; Bulmuş, Özgür; Ülker, Nazife; Yardımcı, Ahmet; Türk, Gaffari; Özcan, Mete
- Abstract
Objective: It is stated that irisin, an exercise hormone, can be anti-obesity effects cause to decreasing of body weight and fat mass by increasing energy consumption. The mechanism of this effect of exogenous irisin treatment on rats is not known exactly. The aim of the present study was to determine the effects of chronic exogenous irisin treatment on body weights and reproductive organ weights in female and male rats in pubertal period. Methods: In this study, totally 48 female and male Sprague-Dawley rats, 21 days old and 35±2 g weight, were divided into control and irisin groups (n=12). The animals started to receive daily intraperitoneally irisin (100 ng/kg) from postnatal day 21 for the about 10 weeks. The control groups received only saline. During the experiment, body weights of all animals were measured weekly. The total weights of the ovaries, uterus, testes, epididymides and ventral prostate were calculated for 100 g body weight at the end of the experiment. Results: When compared to control group, irisin significantly increased the body weight of female rats (p<0.05 for weeks 1 and 2, p<0.001 for weeks 3-7 and p<0.01 for weeks 8 and 9), but no difference in the male rats. Irisin did not affect the weights of the ovaries, uterus, testes and epididymides and also significantly decreased the ventral prostate (p<0.05). Conclusion: In this study, exogenous irisin treatment only cause an increase in body weight of female rats suggests that irisin may have shown this effect by means of a different mechanism in female rats.
- Subjects
GENITALIA; BODY weight; MALE reproductive organs; FEMALE reproductive organs; BODY composition; RATS; CAUSATION (Philosophy)
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2019, Vol 13, Issue S1, pS48
- ISSN
1307-8798
- Publication type
Article