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- Title
HOMOLOGOUS RECOMBINATION REPAIR POLYMORPHISMS AND THE RISK FOR OSTEOSARCOMA.
- Authors
Goričar, Katja; Kovač, Viljem; Jazbec, Janez; Lamovec, Janez; Dolžan, Vita
- Abstract
ackground: DNA repair mechanisms are essential for maintaining genome stability, and genetic variability in DNA repair genes may contribute to cancer susceptibility. Our aim was to evaluate the influence of polymorphisms in the homologous recombination repair genes XRCC3, RAD51, and NBN on the risk for osteosarcoma. Methods: In total, 79 osteosarcoma cases and 373 controls were genotyped for eight single nucleotide polymorphisms (SNPs) in XRCC3, RAD51, and NBN. Logistic regression was used to determine the association of these SNPs with risk for osteosarcoma. Results: None of the investigated SNPs was associated with risk for osteosarcoma in the whole cohort of patients, however, in patients diagnosed before the age of thirty years XRCC3 rs861539 C>T and NBN rs1805794 G>C were associated with significantly decreased risk for osteosarcoma (P=0.047, OR=0.54, 95% CI=0.30–0.99 and P=0.036, OR=0.42, 95% CI=0.19–0.94, respectively). Moreover, in the carriers of a combination of polymorphic alleles in both SNPs risk for osteosarcoma was decreased even more significantly (Ptrend=0.007). The risk for developing osteosarcoma was the lowest in patients with no wild-type alleles for both SNPs (P=0.039, OR=0.31, 95% CI=0.10–0.94). Conclusions: Our results suggest that polymorphisms in homologous recombination repair genes might contribute to risk for osteosarcoma in patients diagnosed below the age of thirty years.
- Subjects
DNA repair; RECOMBINANT DNA; GENETIC polymorphisms; OSTEOSARCOMA; RAD51 recombinase; SINGLE nucleotide polymorphisms; LOGISTIC regression analysis; CANCER risk factors
- Publication
Journal of Medical Biochemistry, 2015, Vol 34, Issue 2, p200
- ISSN
1452-8258
- Publication type
Article
- DOI
10.2478/jomb-2014-0031