We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Diagnostic Outcomes of Pancytopenia after Bone Marrow Examination in Lady Reading Hospital, Peshawar.
- Authors
Riaz, Huma; Shah, Munawar Ali; Khattak, Taj Ali
- Abstract
Objective: To determine the causes of pancytopenia after bone marrow examination to identify the correct etiopathology in order to help in implementing timely and appropriate treatment. Study design: Cross sectional retrospective descriptive study. Place and duration of the study: Haematology unit, department of pathology of Lady Reading Hospital, MTI.Peshawar, from 01.01.2012 to 31.12.2012. Material & Methods; A retrospective analysis of the data of total 181 patients including all ages and both the gender, who presented with pancytopenia and underwent bone marrow examination was performed. Hemoglobin level below 10gm/dl, white blood cell count of less than 4x109 u/l and platelet count less than 150x109/ul was taken as the criteria for pancytopenia. Cell counting was performed by automated cell counter and platelet count was confirmed by peripheral blood film examination. The findings were recorded in a Performa and results were drawn accordingly. Results: During this study period, 181 patients fulfilled the criteria for pancytopenia. Age of study subjects ranged from 1 to 80 years (mean age 26 years). 102(56.4%) were male and 79 (43.6%) were females; giving male to female ratio of 1.2: 1. Among 181 cases, the commonest diagnosis for pancytopenia after bone marrow examination was Aplastic anemia; with 64(35.4%) cases. Megaloblastic anemia was the second commonest diagnosis with 52(28.7 %).31.2(17.6 %)were diagnosed with acute leukemia which included 20 (11 %) and 12 (6.6 %) cases of Acute lymphoblastic leukemia (ALL) and Acute myeloid leukemia (AML) respectively. Chronic lymphocytic leukemia was diagnosed with 2 (1.1 %) cases. while 4 (2.2 %) cases were diagnosed with Myelodysplastic syndrome (MDS) and 3 (1.7 %) with Plasma Cell Disorder/Multiple Myeloma (MM). 2(1.1 %) cases were diagnosed with bone marrow metastasis. Mixed deficiency anemia was found in 5 (2.8 %) cases while 9 (5 %) cases were found with peripheral destruction. Storage cell disorder (Gaucher’s disease) was diagnosed in 2 (1.1%) cases. 5 (2.8 %) cases were diagnosed with Visceral Leishmaniasis and 1 (0.6 %) case diagnosed with Plasmodium Vivax Malaria. Conclusion: Aplastic anemia was the commonest cause of pancytopenia, followed by Megaloblastic anemia after bone marrow examination.
- Subjects
PESHAWAR (Pakistan); BONE marrow examination; PANCYTOPENIA; PLASMA cell diseases; LEUKOCYTE count; GAUCHER'S disease; LYSOSOMAL storage diseases
- Publication
Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 9, p1875
- ISSN
0976-0245
- Publication type
Article
- DOI
10.5958/0976-5506.2019.02728.1