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- Title
A single dose of indomethacin does not prolong premotor reaction time in young, healthy adults: a randomized, placebo-controlled, double-blind, cross-over study.
- Authors
Taskiran, Özden Özyemisci; Can, Asli Gencay; Günendi, Zafer; Beyazova, Mehmet
- Abstract
Objectives: In this study, we aimed to investigate the hypothesis that a single dose of indomethacin may affect information processing speed in healthy subjects. Methods * In this cross-sectional, randomized, placebo controlled, double-blind, cross-over study, 30 healthy adults (8 males, 22 females; mean age 32.4±5.3 years; range 24 to 42 years) received a single dose of 25 mg indomethacin (Endol, oral capsule, DEVA Pharmaceutics, Kartepe, Turkey) and placebo. * Premotor reaction and response times were measured electromyographically before and after the administration of preparations by a blinded researcher in the Electrophysiology Laboratory at Gazi University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara. Results * Premotor reaction time measurements before and after a single dose of indomethacin were 169.1±36.3 and 160.2±29.5 msec, respectively (p=0.113). * Premotor reaction time measurements before and after a single dose of placebo were 158.7±35.5 and 161.5±36.3 msec, respectively (p=0.516). * There was also no statistically significant difference between premotor reaction time measurements of the indomethacin and placebo groups.
- Publication
Turkish Journal of Rheumatology, 2012, Vol 27, Issue 1, p24
- ISSN
1309-0291
- Publication type
Journal Article
- DOI
10.5606/tjr.2012.003