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- Title
<i>In Vitro</i> Bactericidal and Bacteriolytic Activity of Ceragenin CSA-13 against Planktonic Cultures and Biofilms of <i>Streptococcus pneumoniae</i> and Other Pathogenic Streptococci.
- Authors
Moscoso, Miriam; Esteban-Torres, María; Menéndez, Margarita; García, Ernesto
- Abstract
Ceragenin CSA-13, a cationic steroid, is here reported to show a concentration-dependent bactericidal/bacteriolytic activity against pathogenic streptococci, including multidrug-resistant Streptococcus pneumoniae. The autolysis promoted by CSA-13 in pneumococcal cultures appears to be due to the triggering of the major S. pneumoniae autolysin LytA, an N-acetylmuramoyl-L-alanine amidase. CSA-13 also disintegrated pneumococcal biofilms in a very efficient manner, although at concentrations slightly higher than those required for bactericidal activity on planktonic bacteria. CSA-13 has little hemolytic activity which should allow testing its antibacterial efficacy in animal models.
- Subjects
BACTERICIDAL action; BACTERIOLYSIS; PLANKTON culture; BIOFILMS; STREPTOCOCCUS pneumoniae; MULTIDRUG resistance; ANTIBACTERIAL agents
- Publication
PLoS ONE, 2014, Vol 9, Issue 7, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0101037