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- Title
Varfarin direncine neden olan vitamin K epoksit redüktaz (VKOR) gen mutasyonu: Bir vaka takdimi.
- Authors
Keskin Yıldırım, Zuhal; Doğan, Hasan; Büyükavcı, Mustafa
- Abstract
Warfarin is the most widely used drug for prophylaxis and treatment of venous and arterial thromboembolism because of oral intake and its low price. However, it has a narrow therapeutic range, a high rate of bleeding complications, and highly variable dose adjustment between individuals. Dose adjustment is associated with age, gender, weight, height, body surface area, and CYP2C9 and VKORC1 genetic polymorphisms. We report a patient with heterozygous VKORC1 gene mutation who failed to reach a therapeutic level of international normalized ratio (INR) with warfarin therapy.
- Subjects
WARFARIN; VITAMIN K epoxide reductase; MUTAGENESIS; DRUG side effects; DOSE-response relationship in biochemistry; GENETIC polymorphisms; INTERNATIONAL normalized ratio
- Publication
Cocuk Sagligi ve Hastaliklari Dergisi, 2012, Vol 55, Issue 3, p135
- ISSN
0010-0161
- Publication type
Article