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- Title
SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique.
- Authors
Taghizadeh, Eskandar; Kalantar, Seyed Mehdi; Mahdian, Reza; Sheikhha, Mohammad Hasan; Farashahi-Yazd, Ehsan; Ghasemi, Saeed; Shahbazi, Zahra
- Abstract
Background: Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics. Objective: Study of SULF1 gene polymorphism with fetus failure in in vitro fertilization (IVF) technique. Materials and Methods: We studied one common (minor allele frequency >0.05) regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls. Results: We found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p<0.001). Conclusion: These findings suggest that SULF1 genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim.
- Subjects
GENETIC polymorphism research; FERTILIZATION in vitro; HUMAN in vitro fertilization; POLYMERASE chain reaction; RESTRICTION fragment length polymorphisms
- Publication
Iranian Journal of Reproductive Medicine, 2015, Vol 13, Issue 4, p215
- ISSN
1680-6433
- Publication type
Article