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- Title
Biologic variability in NT-pro BNP and cardiac troponin-I in healthy dogs and dogs with mitral valve degeneration.
- Authors
Ruaux, Craig; Scollan, Katherine; Suchodolski, Jan S.; Steiner, Jörg M.; Sisson, D. David
- Abstract
Background The N-terminal fragment of the prohormone B-type natriuretic peptide ( NT-pro BNP) and cardiac troponin-I are candidate biomarkers for cardiac disease in dogs. The degree of biologic variation in these biomarkers has not previously been reported in healthy dogs or dogs with mitral regurgitation. Objectives The purpose of the study was to derive estimates of intrinsic biologic variability and reference change values for NT-pro BNP and cardiac troponin-I in healthy dogs and dogs with mitral regurgitation grade IB and II according to the International Small Animal Cardiac Health Council ( ISACHC) grading system. Methods Plasma and sera were collected weekly for up to 7 weeks from 12 control dogs and 9 dogs with mitral regurgitation. NT-pro BNP and troponin-I (C-TnI) concentrations were determined. Indices of biologic variation such as reciprocal index of individuality (r-IoI) and reference change values ( RCV) were calculated in both the groups. Results Individuality was high in control dogs and dogs with grade IB and II mitral valve regurgitation for both C-TnI (r-IoI 1.6 and 2) and NT-pro BNP (1.5 and 2.7), while the 2-sided RCV for NT-pro BNP was significantly lower in dogs with mitral regurgitation (52.5% vs 99.4%, P<0.01.). Conclusions High individuality of these cardiac biomarkers suggests that, following diagnosis, these assays are best interpreted by serial determination in individual canine patients rather than by comparison to a population-based reference interval. The smaller RCV values for dogs with mitral regurgitation suggest that smaller relative changes in NT-pro BNP are clinically meaningful in these patients.
- Subjects
NATRIURETIC peptides; HEART diseases; DOG diseases; MITRAL valve; TROPONIN I; BIOMARKERS
- Publication
Veterinary Clinical Pathology, 2015, Vol 44, Issue 3, p420
- ISSN
0275-6382
- Publication type
Article
- DOI
10.1111/vcp.12268