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- Title
Detecting and characterizing circular RNAs.
- Authors
Jeck, William R; Sharpless, Norman E
- Abstract
Circular RNA transcripts were first identified in the early 1990s but knowledge of these species has remained limited, as their study through traditional methods of RNA analysis has been difficult. Now, novel bioinformatic approaches coupled with biochemical enrichment strategies and deep sequencing have allowed comprehensive studies of circular RNA species. Recent studies have revealed thousands of endogenous circular RNAs in mammalian cells, some of which are highly abundant and evolutionarily conserved. Evidence is emerging that some circRNAs might regulate microRNA (miRNA) function, and roles in transcriptional control have also been suggested. Therefore, study of this class of noncoding RNAs has potential implications for therapeutic and research applications. We believe the key future challenge for the field will be to understand the regulation and function of these unusual molecules.
- Subjects
MICRORNA; GENETIC transcription; GENE expression; GENE amplification; NON-coding RNA
- Publication
Nature Biotechnology, 2014, Vol 32, Issue 5, p453
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt.2890