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- Title
Making antibodies from scratch.
- Authors
Love, J. Christopher
- Abstract
The article focuses on an experiment about the synthesis and screening of antibody fragments designed in silico and synthesized de novo. Findings affirmed the contribution of the rational approaches for looking at the relationships between the sequences and activities of a library of molecules in developing new therapeutic antibodies. Also described ia an approach involving the display of in vitro libraries of recombinant antibodies on the surfaces of organisms like yeast or bacteria.
- Subjects
THERAPEUTIC use of immunoglobulins; MOLECULES; MEDICAL libraries; BIOLOGICAL libraries; BACTERIA
- Publication
Nature Biotechnology, 2010, Vol 28, Issue 11, p1176
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt1110-1176