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- Title
Novel DICER1 mutation as cause of multinodular goiter in children.
- Authors
Darrat, Ilaaf; Bedoyan, Jirair K.; Chen, Ming; Schuette, Jane L.; Lesperance, Marci M.; Irish, Jonathan
- Abstract
Background The aim of this report was to present a rare case of an adolescent with multinodular goiter (MNG) found to have a DICER1 mutation. Methods and Results The methodology includes a presentation and discussion of a chart review including endocrine hormone tests, thyroid ultrasound, and genetic testing for DICER1. A 12-year-old girl presented with a diffusely enlarged thyroid gland. Family history revealed an older sister with a history of bilateral ovarian Sertoli-Leydig cell tumors and MNG. Thyroid function tests were normal. Serial thyroid ultrasounds showed enlarging multiple bilateral nodules. Fine-needle aspiration suggested MNG. Genetic testing revealed a novel heterozygous premature termination mutation (c.1525C>T p.R509X) in the DICER1 gene. Conclusions Thyroid nodules are rare in children but carry a higher risk for malignancy. It is essential to inquire about family history and refer for genetic evaluation with a family history of MNG. In patients with DICER1 mutations, tumor surveillance is critical due to the increased risk of multiple tumors, including ovarian tumors and pleuropulmonary blastoma. © 2013 Wiley Periodicals, Inc. Head Neck 35: E369-E371, 2013
- Subjects
THYROID disease diagnosis; GOITER; CANCER risk factors; ROOT-tubercles; LEYDIG cell tumors; SERTOLI cell tumors; OVARIAN tumors; DISEASE risk factors
- Publication
Head & Neck, 2013, Vol 35, Issue 12, pE369
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23250