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- Title
Isolation and identification of inhibitory compounds on TNF-α production from Magnolia fargesii.
- Authors
Chae, Sook-Hee; Kim, Pyoung-Su; Cho, Jae-Youl; Park, Ji-Soo; Lee, Jae-Ho; Yoo, Eun-Sook; Baik, Kyong-Up; Lee, Jong-Soo; Park, Myung-Hwan
- Abstract
Three TNFα-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-α production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC=51 µM).
- Publication
Archives of Pharmacal Research, 1998, Vol 21, Issue 1, p67
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF03216755