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- Title
Opposite paracrine effects of 5-HT and dopamine on Na<sup>+</sup>-Pi cotransport in opossum kidney cells.
- Authors
de Toledo, Frederico G. S.; Beers, Kelly W.; Berndt, Theresa J.; Thompson, Michael A.; Tyce, Gertrude M.; Knox, Franklyn G.; Dousa, Thomas P.
- Abstract
Opposite paracrine effects of 5-HT and dopamine on Na +-Pi cotransport in opossum kidney cells. The proximal tubule is the major site of Pi reabsorption in the nephron. The rate-limiting step in this process is the active transport of Pi from the tubular fluid across the brush-border membrane via the Na+-Pi cotransporter. Recent evidence shows that Na+-Pi cotransport is not only regulated by multiple extrarenal hormones, but also in a paracrine/autocrine manner by dopamine that is synthesized by proximal tubule epithelial cells.
- Subjects
DOPAMINE; PARACRINE mechanisms; SODIUM cotransport systems; HORMONES; AUTOCRINE mechanisms; KIDNEYS
- Publication
Kidney International, 1997, Vol 52, Issue 1, p152
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1997.314