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- Title
Prediction of survival with combining quantitative <sup>18</sup>F‐FDG PET/CT and DW‐MRI parameters in sinonasal malignancies.
- Authors
Ozturk, Kerem; Gencturk, Mehmet; Caicedo‐Granados, Emiro; Li, Faqian; Cayci, Zuzan
- Abstract
Background: We aimed to establish the prognostic value of 18F‐fluoro‐deoxy‐glucose positron emission/CT (18F‐FDG PET/CT) and diffusion‐weighted (DW) MRI in determining overall survival (OS), progression‐free survival (PFS), and distant metastasis‐free survival (DMFS) of sinonasal malignancies. Methods: Sixty‐eight patients with sinonasal cancer who underwent both pretreatment 18F‐FDG PET/CT scan and head‐neck MRI from January 2009 through August 2017 were retrospectively reviewed. Kaplan‐Meier survival analysis of 18F‐FDG PET/CT and DW‐MRI parameters were performed for OS, PFS, and DMFS. Results: Cox regression analysis determined that all the quantitative 18F‐FDG PET/CT and DW‐MRI parameters were independently correlated with PFS, DMFS, and OS (P < .05). After controlling for imaging variables, perineural invasion (P = .02) and ill‐defined margin (P = .02) were found to be significantly correlated with shorter OS; while the perineural invasion was significantly correlated with shorter PFS (P = .02). Conclusions: The pretreatment DW‐MRI and 18F‐FDG PET/CT parameters could be substantial surrogate markers for sinonasal malignancies.
- Subjects
POSITRON emission; PROGRESSION-free survival; BIOMARKERS; REGRESSION analysis
- Publication
Head & Neck, 2019, Vol 41, Issue 9, p3080
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25799