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- Title
Effects of E-cadherin ( CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer.
- Authors
Chien, Ming-Hsien; Chou, Lin Shih-Shen; Chung, Tsung-Te; Lin, Chien-Huang; Chou, Ming-Yung; Weng, Meng-Shih; Yang, Shun-Fa; Chen, Mu-Kuan
- Abstract
Background This study investigates the association between polymorphism in the E-cadherin/ CDH1 promoter region and the risk and progression of oral cancer. Methods Genetic polymorphisms of CDH1-160 and -347 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 347 noncancer controls and in 251 patients with oral cancer. Results The statistical analysis showed that subjects with at least 1 varied GA allele of CDH1-347 polymorphic genotypes or combinations of the CDH1-160 CA/-347 GGA, CDH1-160 CC/-347 GGA, or CDH1-160 CC/-347 GAGA genotypes had a significantly higher risk, whereas subjects with CDH1-160 C/A or A/A had a significantly lower risk of developing oral cancer than those with wild-type genotypes. Furthermore, elderly patients with the CDH1-347 G/GA or GA/GA genotype were associated with a higher incidence in lymph node metastasis than were those with the G/G genotype. Conclusions These results suggest that CDH1-347 polymorphisms are associated with increased risks of oral cancer, and may be a predictive factor for tumor lymph node metastasis. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
- Subjects
CADHERINS; ORAL cancer; ORAL medicine; GENETIC polymorphisms; CANCER genetics; LYMPH node cancer
- Publication
Head & Neck, 2012, Vol 34, Issue 3, p405
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21746