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- Title
Direct fluorescence visualization of clinically occult high-risk oral premalignant disease using a simple hand-held device.
- Authors
Poh, Catherine F.; Ng, Samson P.; Williams, P. Michele; Zhang, Lewei; Laronde, Denise M.; Lane, Pierre; MacAulay, Calum; Rosin, Miriam P.
- Abstract
Background A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method to identify such occult change is needed. Methods Patients in the Oral Dysplasia Clinics at British Columbia are currently being examined with a simple hand-held device that permits the direct visualization of alterations to autofluorescence in the oral cavity. Tissue showing loss of autofluorescence is biopsied. Results We present 3 representative cases in which occult lesions were identified with fluorescence visualization during longitudinal follow-up, resulting in the diagnosis of a primary dysplasia in case 1, a second primary cancer in case 2, and cancer recurrence in case 3. Conclusions This is the first report of the diagnosis of occult oral disease using a simple noninvasive device. These early examples indicate the potential value of this technology to guide the management of patients with oral lesions, facilitating the detection of high-risk changes not apparent with white-light visualization. © 2006 Wiley Periodicals, Inc. Head Neck, 2006
- Subjects
TREATMENT of oral cancer; PRECANCEROUS conditions; FLUORESCENCE spectroscopy; DYSPLASIA; CANCER relapse; NONINVASIVE diagnostic tests; CANCER-related mortality; PATIENTS
- Publication
Head & Neck, 2007, Vol 29, Issue 1, p71
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.20468