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- Title
Differential associations between brain 5-HT<sub>1A</sub> receptor binding and response to pain versus touch.
- Authors
Martikainen, Ilkka K.; Hirvonen, Jussi; Pesonen, Ullamari; Hagelberg, Nora; Laurikainen, Heikki; Tuikkala, Heikki; Kajander, Jaana; Någren, Kjell; Hietala, Jarmo; Pertovaara, Antti
- Abstract
We studied whether brain serotonin 5-HT1A receptor availability is associated with response to noxious heat versus tactile stimuli, and short-term memory for heat pain. Psychophysical performance was assessed in 16 healthy subjects who had participated in a positron emission tomography study using [ carbonyl-11C]WAY-100635 ligand for the assessment of 5-HT1A receptor binding potential ( BPND). Signal detection theory was applied to allow separate analysis of the subject’s sensory-discriminative capacity (sensory factor) and the attitude toward reporting a sensation (response criterion; non-sensory factor). Subject’s response criterion for heat pain was inversely correlated with 5-HT1A BPND in the dorsal raphe, middle temporal gyrus, orbitofrontal cortex and posterior cingulum, whereas the subject’s discriminative capacity for touch was inversely correlated with 5-HT1A BPND in the cingulum, inferior temporal gyrus, and medial prefrontal cortex. Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT1A BPND in the dorsal raphe.
- Subjects
PAIN; SHORT-term memory; POSITRON emission tomography; SEROTONIN; TOUCH; SIGNAL detection; PREFRONTAL cortex
- Publication
Journal of Neural Transmission, 2009, Vol 116, Issue 7, p821
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-009-0248-3