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- Title
Interleukin-10 production by lung macrophages in CBAxidmutant mice infected withMycobacterium tuberculosis.
- Authors
Junqueira-Kipnis, Ana Paula; Kipnis, Andre; Henao Tamayo, Marcela; Harton, Marisa; Gonzalez Juarrero, Mercedes; Basaraba, Randall J.; Orme, Ian M.
- Abstract
Mice on the CBA inbred strain background expressing the well characterized mutation designatedxidin the cytoplasmic signalling enzyme Bruton's protein kinase have been previously noted to illustrate shifts in T helper type 1 (Th1)/Th2 immunity which is underlined by an apparent failure to produce the regulatory cytokine interleukin-10. In the current study we examined if this extended to infection withMycobacterium tuberculosis, which also depends on Th1 immunity. Contrary to expectations,xidmice showed evidence of a transient early susceptibility to pulmonary infection, changes in macrophage morphology, and decreased activation of lung natural killer cells, while showing evidence of substantial IL-10 production and accumulation in lung lesions macrophages, but paradoxically this did not influence the course of the chronic disease. In addition, macrophages from the lungs ofxidmice also expressed high levels of CD14. These observations suggest that thexidmutation in cellular signalling has much wider effects on the immune system than previously thought.
- Subjects
INTERLEUKIN-10; INTERLEUKINS; MACROPHAGES; MYCOBACTERIUM tuberculosis; CELLULAR immunity; TH1 cells
- Publication
Immunology, 2005, Vol 115, Issue 2, p246
- ISSN
0019-2805
- Publication type
Article
- DOI
10.1111/j.1365-2567.2005.02136.x