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- Title
Modulation of WC1, a lineage-specific cell surface molecule of γ/δ T cells, augments cellular proliferation.
- Authors
Hanby-Flarida, M. D.; Trask, O.J.; Yang, T.J.; Baldwin, C.L.
- Abstract
WC1, also known as T19, is the only unique γ/δ T-cell differentiation antigen described to date other than the γ/δ T-cell receptor. We present evidence that modulation of WC1 results in augmented proliferation of γ/δ T cells. Immobilized IL-A29, a monoclonal antibody (mAb) specific for WC1, augmented proliferation of γ/δ T cells in the autologous mixed leucocyte reaction (AMLR) as well as proliferation induced by either anti-CD3 or anti-CD5 mAb. In contrast, anti-CD5 mAb did not increase proliferation in the AMLR even though both CD5 and WC1 are members of the scavenger receptor cysteine-rich family of proteins and are expressed by bovine peripheral brood γ/δ T cells. IL-A29 did not induce proliferation when assessed alone or in the presence of either phorbol myristate acetate (PMA) or interleukin-2. IL-A29 also did not induce detectable calcium mobilization when evaluated in the presence of monocytes, PMA, or following cross-linking of IL-A29 with anti-immunoglobulin antibody. We conclude that WC1 is a γ/δ T-cell lineage-specific cell-surface differentiation antigen which is involved in activation of γ/8 T cells using an as yet unidentified pathway.
- Subjects
CD antigens; CD4 antigen; T cells; TH1 cells; TH2 cells; INTERLEUKIN-4; SELECTINS
- Publication
Immunology, 1996, Vol 88, Issue 1, p116
- ISSN
0019-2805
- Publication type
Article
- DOI
10.1046/j.1365-2567.1996.d01-649.x