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- Title
Total White Blood Cell Count is Associated with Arterial Stiffness Among Hypertensive Patients.
- Authors
Huang, Min; Li, Fajiu; Chen, Si; Liu, Min; Qin, Wei; Wu, Juanjuan; Chen, Ying; Zhong, Jinnan; Zhao, Qian; Hu, Bingzhu
- Abstract
The association between white blood cell (WBC) count and arterial stiffness in patients with hypertension is not well-documented. We aimed to examine the relationships of total WBC count with arterial stiffness and risk of macrovascular damage in hypertensive patients. A total of 631 hypertensive adults (mean age: 65.6 years) were included in the present study. Arterial stiffness was determined by brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI). Macrovascular damage was defined as baPWV >1.8 m/s or ABI <.9. The dose-response associations were assessed by multivariate linear or logistic regression models. After multivariate adjustments, we observed a dose-response relationship between increasing total WBC count and arterial stiffness. Participants in the highest tertile of total WBC count showed a significantly elevated baPWV (β =.088; 95% CI:.021,.154; P trend =.010) and reduced ABI (β = −.027; 95% CI: −.046, −.008; P trend =.005), as compared with those in the first tertile. The association was similar in different subgroups. In addition, elevated total WBC count was related to a greater risk of macrovascular damage, as indicated by baPWV >1.8 m/s (OR = 1.86; 95% CI: 1.15, 2.99, comparing the extreme tertiles). Our data suggest that elevated total WBC count was related to arterial stiffness among individuals with hypertension.
- Subjects
HYPERTENSION; CONFIDENCE intervals; CROSS-sectional method; REGRESSION analysis; ARTERIAL diseases; RISK assessment; PULSE wave analysis; LEUKOCYTE count; DESCRIPTIVE statistics; RESEARCH funding; ODDS ratio; LOGISTIC regression analysis
- Publication
Angiology, 2023, Vol 74, Issue 7, p657
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/00033197221115566