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- Title
Tolbutamide stimulates gastric somatostatin release from isolated perfused rat stomach.
- Authors
Chiba, Tsutomu; Taminato, Tomohiko; Kadowaki, Seizo; Chihara, Kazuo; Matsukura, Shigeru; Seino, Yutaka; Fujita, Takuo; Chiba, T; Taminato, T; Kadowaki, S; Chihara, K; Matsukura, S; Seino, Y; Fujita, T
- Abstract
The effect of tolbutamide on somatostatin release from the isolated perfused stomach was investigated in both normal and streptozotocin-diabetic rats. Tolbutamide (10, 100, and 1000 microgram/ml) evoked a significant and dose-dependent increase in gastric somatostatin release. The tolbutamide (100 microgram/ml)-induced gastric somatostatin secretion was not influenced by differences in glucose concentration (1.5, 5.5, and 16.5 mM) throughout the perfusion period. Tolbutamide (100 microgram/ml)-induced gastric somatostatin release in streptozotocin-diabetic rats was significantly higher than in normal rats. Thus, tolbutamide is a potent secretagogue for gastric somatostatin secretion, and this effect is more prominent in diabetic animals.
- Publication
Diabetes, 1982, Vol 31, Issue 2, p119
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.31.2.119