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- Title
Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis.
- Authors
Meng, Rijing; Xu, Jialei; Fan, Chenrui; Liao, Haiqing; Wu, Zeni; Zeng, Qixin
- Abstract
Background: Cardiovascular disease (CVD) is the leading cause of mortality in the world. Patients with periodontitis have a higher risk of CVD, although a causal relationship between these conditions remains unclear. Non-surgical periodontal therapy (NSPT) is able to control inflammation at local and systemic levels. This study aimed to analyze the effect of NSPT on CVD risk markers. Methods: Four electronic databases were searched from their inception to April 1, 2023, to identify and select articles without any language restrictions. Eleven CVD-related markers (e.g., C-reactive protein [CRP], Interleukin-6 [IL-6]) were selected. Meta-analyses were performed using random and fixed effect models. The differences were expressed as weighted mean differences (WMD) and 95% confidence interval (95% CI). Results: From 1353 studies, twenty-one randomized controlled clinical trials were included in the meta-analysis. Results showed a significant decrease in CRP, IL-6, and systolic blood pressure (SBP) after NSPT. Conclusion: Moderate certainty evidence shows that NSPT has a positive effect on the reduction of IL-6 and SBP in patients with periodontitis, while low certainty evidence shows that NSPT is effective for reduction of CRP. Moderate certainty evidence showed that NSPT did not show a positive effect on low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC) and triglycerides (TG), and low certainty evidence showed that NSPT did not show a positive effect on Interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), diastolic blood pressure (DBP), and flow-mediated dilatation (FMD). Protocol Registration: The protocol was registered in the PROSPERO (International Prospective Register of Systematic Reviews), number CRD42022377565.
- Subjects
PERIODONTITIS treatment; CARDIOVASCULAR disease prevention; RISK assessment; MEDICAL information storage &; retrieval systems; RESEARCH funding; TREATMENT effectiveness; CARDIOVASCULAR diseases risk factors; META-analysis; DESCRIPTIVE statistics; SYSTEMATIC reviews; MEDLINE; MEDICAL databases; DEBRIDEMENT; CONFIDENCE intervals; SYSTOLIC blood pressure; ONLINE information services; BIOMARKERS; C-reactive protein; INTERLEUKINS
- Publication
BMC Oral Health, 2024, Vol 24, Issue 1, p1
- ISSN
1472-6831
- Publication type
Article
- DOI
10.1186/s12903-024-04433-0