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- Title
Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride esters.
- Authors
PANTELIĆ, NEBOJŠA; ZMEJKOVSKI, BOJANA B.; STANOJKOVIĆ, TATJANA P.; JEVTIĆ, VERICA V.; RADIĆ, GORDANA P.; TRIFUNOVIĆ, SREĆKO R.; KALUĐEROVIĆ, GORAN N.; SABO, TIBOR J.
- Abstract
A novel (S,S)-R2eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine--N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, ¹H- and 13C-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R2eddip esters, dialkyl (S,S)-ethylenediamine- N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50 (Fem-x) value of 1.51±0.09 μM.
- Subjects
CELL-mediated cytotoxicity; ESTERS; CHEMICAL synthesis; ETHYLENEDIAMINE; IN vitro studies; NUCLEAR magnetic resonance spectroscopy; CISPLATIN; CANCER cells
- Publication
Journal of the Serbian Chemical Society, 2014, Vol 79, Issue 6, p649
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC130512022P