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- Title
Adult-onset idiopathic opsoclonus-myoclonus syndrome.
- Authors
Xiaohan Zhang; Wenjing Yan; Yuqiang Song; Haifang Zhu; Yanping Sun
- Abstract
Purpose: Opsoclonus-myoclonus syndrome is extremely uncommon in adults with an autoimmune pathophysiology. Because of the rarity of the syndrome, international recognition of opsoclonus-myoclonus-ataxia syndrome needs to be improved urgently. Therefore, the goal of this study was to raise the awareness of the opsoclonus-myoclonus-ataxia syndrome and help doctors in better diagnosing and using immunotherapy. Methods: We present a case study of an adult-onset case of idiopathic opsoclonus-myoclonus syndrome characterized by spontaneous arrhythmic multidirectional conjugate eye movements, myoclonus, ataxia, sleep disorders, and intense fear. Additionally, we conduct a literature search and summarize the pathophysiology, clinical presentation, diagnosis, and treatment of opsoclonus-myoclonus-ataxia syndrome. Results: Immunotherapies successfully treated the patient's opsoclonus, myoclonus, and ataxia. Further, the article also includes an update summary of the opsoclonus--myoclonus-ataxia syndrome. Conclusion: The prevalence of residual sequela in adults with opsoclonus-myoclonus-ataxia syndrome is low. Early diagnosis and treatment may result in a better prognosis. Furthermore, combined immunotherapy is expected to reduce the incidence of refractory and reoccurring opsoclonus-myoclonus-ataxia syndrome.
- Subjects
OPSOCLONUS-Myoclonus syndrome; MYOCLONUS; CONSCIOUSNESS raising; SYMPTOMS; SLEEP disorders; EYE movements
- Publication
Arquivos Brasileiros de Oftalmologia, 2024, Vol 87, Issue 4, p1
- ISSN
0004-2749
- Publication type
Article
- DOI
10.5935/0004-2749.2022-0024