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- Title
Cyclohexylamine -- An efficient organocatalyst for the synthesis of 2-amino-4H-chromene derivatives by multicomponent reactions of salicylaldehydes, active methylene compounds and nitroalkanes.
- Authors
Mitragotri, Satish D.; Khyadage, Poonam H.; Chorghade, Diksha S.; Kulkarni, Makarand A.; Wadagaonkar, Prakash P.
- Abstract
Cyclohexylamine was found to be an efficient organocatalyst for the synthesis of structurally diverse 2-amino- 4H-chromenes by multicomponent reaction of (substituted) salicylaldehydes, active methylene compounds and nitroalkanes at ambient temperature and under solvent-free conditions. The synthesis of a variety of 2- amino-4H-chromenes was achieved using the reaction of (substituted) salicylaldehydes with two different C-H acids. The present protocol, which employed commercially available cyclohexylamine as an organocatalyst, offered the advantages of operational simplicity and avoidance of conventional purification methods and the obtained products were essentially pure.
- Subjects
METHYLENE compounds; CYCLOHEXYLAMINE; NITROALKANES
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2023, Vol 2023, p1
- ISSN
1551-7004
- Publication type
Article
- DOI
10.24820/ark.5550190.p012.118