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- Title
CFTR modulators for cystic fibrosis.
- Authors
BERTONCINI, ERICA; COLOMB-LIPPA, DAWN
- Abstract
The article discusses the development of cystic fibrosis transmembrane conductance regulator (CFTR) modulators for cystic fibrosis (CF), the first pharmacologic agents targeting the mutated CFTR channel, the fundamental defect of CF. The authors explain that Ivacaftor has a positive impact on lung function in as early as two weeks after initiation, with a 17.2 percent improvement in forced expiratory volume in the first second of expiration (FEV1).
- Subjects
CYSTIC fibrosis; MEMBRANE proteins; GENETICS; THERAPEUTICS
- Publication
JAAPA: Journal of the American Academy of Physician Assistants (Haymarket Media, Inc.), 2013, Vol 26, Issue 2, p59
- ISSN
1547-1896
- Publication type
Article
- DOI
10.1097/01720610-201302000-00013