A randomized trial comparing ketamine infusion to placebo in heart transplant, a high-risk vasoplegia population, will shed light on the interaction of ketamine on the risk of vasoplegia. Ketamine, a potent analgesic and amnestic, is known to have IL-6-inhibiting properties.[[13]],[[14]],[[15]] Ketamine comes in two forms: racemic (most commonly available), and S-ketamine (esketamine, Spravato SP ® sp ).