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- Title
Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus.
- Authors
Bellini, Carlo; Campone, Francesco; Serra, Giovanni
- Abstract
Patent ductus arteriosus is one of the most common congenital abnormalities found in premature infants. Ibuprofen, a nonsteroidal drug that is commonly used as an antipyretic, analgesic and anti-inflammatory agent, is also used to induce closure of symptomatic patent ductus arteriosus in preterm infants. Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension. Only 3 cases of pulmonary hypertension following early administration of an ibuprofen solution buffered with tromethamine have previously been reported. However, this severe side effect has never been observed in multicentre, randomized, double-blind controlled trials, nor in recent reviews or meta-analyses of L-lysine ibuprofen use.
- Subjects
PATENT ductus arteriosus; CONGENITAL heart disease; DUCTUS arteriosus abnormalities; HEART blood-vessel abnormalities; MEDICAL care
- Publication
Canadian Medical Association Journal (CMAJ), 2006, Vol 174, Issue 13, p1843
- Publication type
Article
- DOI
10.1503/cmaj.051446