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- Title
RANDOMIZED CONTROL TRIAL BETWEEN SINGLE PHOTOTHERAPY PLUS LOW-COST WHITE CURTAIN AND CONVENTIONAL PHOTOTHERAPY.
- Authors
Djokomuljanto, S.; B. S., Quah; Y., Surini; R., Noraida; A. N. I., Nik Zainal; Hansen, T. W. R.; Van Rostenberghe, H.
- Abstract
PURPOSE : To determine whether the addition of low-cost reflecting curtains to a standard phototherapy unit could increase effectiveness of phototherapy for neonatal jaundice. METHODS : This is a randomised controlled clinical trial, performed in the level one nursery of a tertiary University Hospital in Malaysia. The subjects were term newborns with uncomplicated neonatal jaundice presenting in the first week of life. Phototherapy with white curtains hanging from the sides of the phototherapy unit (study group) was compared to single phototherapy without curtains (control group). The primary outcome measure was the mean difference in total serum bilirubin measured at baseline and after four hours of phototherapy. The secondary outcome was the duration of phototherapy. RESULTS : There were 50 babies in the study group and 47 babies in the control group. The mean decrease in total serum bilirubin levels after 4 hours of phototherapy was significantly (p<0.001) greater in the study group (27.62 µmol/L, SD 25.24) compared to that of the control group (4.04 µmol/L, SD 24.27). Cox proportional hazards regression analysis indicated that the median duration of phototherapy was significantly shorter in the study group (10 hours) than in the control group (34 hours) (chi-square-change = 38.93; p<0.001; hazards ratio: 0.21; 95% confidence interval, 0.13 to 0.35). No difference in adverse events was noted in terms of hyper- or hypothermia, weight loss, skin rash, loose stools, or feeding intolerance. CONCLUSION : Hanging white curtains around phototherapy units significantly increases its efficacy in the treatment of neonatal jaundice without evidence of increased adverse effects.
- Subjects
MALAYSIA; PHOTOTHERAPY; NEONATAL jaundice; UNIVERSITIES &; colleges; CLINICAL trials; INSTITUTIONAL linens
- Publication
Malaysian Journal of Medical Sciences, 2006, Vol 13, p46
- ISSN
1394-195X
- Publication type
Article