We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
THE EVALUATION OF BIOLOGICAL EFFECT OF CYTOTOXIC PEPTIDES ON TUMOR CELL LINES.
- Authors
Pascariu, M.; Anghelache, A. Nevoie; ConstantinescU, D.; Jitaru, D.; Carasevici, E.; Luchian, T.
- Abstract
This study evaluated the cytotoxic effect produced by Magainin II, Cecropin A and Cecropin B on four tumor cell lines. The cytotoxic effect of the Magainin II, Cecropin A and Cecropin B by the MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] viability test was evaluated. Peptides used did not show the same cytotoxic effect on all cell lines tested; which means that the cytotoxic effect of tested peptides depends on the tumor cell used in this experiment. Cytotoxic effect was more pronounced with increasing concentration of peptide. The antimicrobial peptides used in our experiment had variable potential on A549 human alveolar carcinoma cells.
- Subjects
MAGAININS; ANTIBODY-dependent cell cytotoxicity; CANCER cells; CELL lines; BROMIDES
- Publication
Digest Journal of Nanomaterials & Biostructures (DJNB), 2012, Vol 7, Issue 1, p79
- ISSN
1842-3582
- Publication type
Article