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- Title
Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography.
- Authors
De Luca, Chiara; Buratti, Alessandro; Krauke, Yannick; Stephan, Svea; Monks, Kate; Brighenti, Virginia; Pellati, Federica; Cavazzini, Alberto; Catani, Martina; Felletti, Simona
- Abstract
This work reports about a screening of four adsorbents with different polarity employed for the separation of the main phytocannabinoids contained in Cannabis sativa L., under normal phase liquid chromatography (NPLC). The effect of polarity and type of interaction mechanisms of the adsorbents (namely Si-, CN-, Diol-, and NH2-based SPs) on retention has been investigated under a variety of conditions either by using different combinations of apolar solvents (heptane or hexane) and alcohols (ethanol or isopropanol). The columns have also been employed for the separation of a real cannabis sample.
- Subjects
NORMAL-phase chromatography; CANNABINOIDS; HEPTANE; CANNABIS (Genus); ISOPROPYL alcohol; SORBENTS
- Publication
Analytical & Bioanalytical Chemistry, 2022, Vol 414, Issue 18, p5385
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-021-03862-y