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- Title
Ag2WO4 nanoparticles radiolabeled with technetium-99m: a potential new tool for tumor identification and uptake.
- Authors
Santos, Carla Júnia; Filho, Francisco Moura; Campos, Fernanda Lapa; Ferreira, Carolina de Aguiar; de Barros, André Luís Branco; Soares, Daniel Crístian Ferreira
- Abstract
Silver tungstate nanoparticles have been presenting attractive characteristics that could allow its usage in the biomedical sciences. In this study, Ag2WO4 nanoparticles with an average size of 242 nm were obtained and radiolabeled with technetium-99m with high labeling-yield as well as high stability. Biodistribution studies were carried out in healthy and tumor-bearing mice to determine the nanoparticle's in vivo behavior. The results revealed an important tumor-to-muscle ratio, reaching values above than 1.5, demonstrated the ability of this nanomaterial in accumulating preferentially in tumor tissue. All results together, converge to consider the Ag2WO4 nanoparticles as a potential system against cancer and a potential new radiolabeled probe for tumor identification and uptake.
- Subjects
MEDICAL sciences; RADIOACTIVE tracers; SILVER nanoparticles; TUMORS; IDENTIFICATION; NANOPARTICLES
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2020, Vol 323, Issue 1, p51
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-019-06955-2