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- Title
The generation of hydrophilic polypeptide-siloxane conjugates via n-carboxyanhydride polymerisation.
- Authors
Thornton, Paul; Brannigan, Ruairi; Podporska, Joanna; Quilty, Brid; Heise, Andreas
- Abstract
A novel methodology to create covalently linked polypeptide-siloxane hybrid materials by controlled n-carboxyanhydride ring opening polymerisation is disclosed. Poly- l-glutamic acid and poly- l-lysine conjugated products were formed that possessed excellent surface wettability. In addition, the poly- l-lysine-siloxane hybrids formed demonstrated bactericidal attributes against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. It is anticipated that these materials may be of significance for the generation of hydrophilic siloxane-containing polymers that are commonly employed in contemporary medical devices.
- Subjects
POLYMERIZATION research; GLUTAMIC acid; POLYPEPTIDES; POLYMERS; MEDICAL equipment
- Publication
Journal of Materials Science: Materials in Medicine, 2012, Vol 23, Issue 1, p37
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-011-4503-4