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- Title
Multi‐Gram Scale Synthesis of Chiral 3‐Methyl‐2,5‐trans‐tetrahydrofurans.
- Authors
Qin, Shuanglin; Cao, Yuting; Luo, Yunhao; Jiang, Shende; Clark, J. Stephen; Wang, Xiaoji; Yang, Guang
- Abstract
In this article, we report the rapid and facile synthesis of chiral 3‐methyl‐2,5‐trans‐tetrahydrofurans. This reaction utilizes cheap and easily available starting materials. A domino hydrolysis and intramolecular Michael‐type ring closure reaction was the key step. As a result, synthesis of the desired 3‐methyl‐2,5‐trans‐tetrahydrofurans could be achieved in gram‐scale over seven linear steps with high chemical yield and high diastereoselectivity.
- Subjects
CHEMICAL yield; HYDROLYSIS
- Publication
Helvetica Chimica Acta, 2019, Vol 102, Issue 7, pN.PAG
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201900131