We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemical Constituents from the Fermented Mycelia of the Medicinal Fungus Xylaria nigripes.
- Authors
Xiong, Juan; Huang, Ya; Wu, Xi-Ying; Liu, Xin-Hua; Fan, Hui; Wang, Wei; Zhao, Yun; Yang, Guo-Xun; Zhang, Hai-Yan; Hu, Jin-Feng
- Abstract
Nineteen compounds mainly including pyrrole-containing alkaloids and phytosterols were isolated from the EtOH extract of the fermented mycelia of Xylaria nigripes, a precious medicinal fungus known as Wuling Shen in Chinese. On the basis of spectroscopic methods, the structures of the new naturally occurring compounds were determined to be (4 S)-3,4-dihydro-4-(4-hydroxybenzyl)-3-oxo-1 H-pyrrolo[2,1- c][1,4]oxazine-6-carbaldehyde ( 1), methyl (2 S)-2-[2-formyl-5-(hydroxymethyl)-1 H-pyrrol-1-yl]-3-(4-hydroxyphenyl)propanoate ( 2), and 3-{4-[(2 R)-(2,3-dihydroxy-3-methylbutoxy]phenyl}-7-hydroxy-4 H-chromen-4-one ( 3), respectively. The absolute configurations of 1 and 2 were deduced by the observed Cotton effects in their circular dichroism (CD) spectra, whereas that of the 1,2-diol moiety in 3 was determined using the Snatzke's method. Their biological activities such as neuroprotective, anti-neuroinflammatory, and cytotoxic properties were also reported.
- Subjects
XYLARIA; FUNGI; XYLARIACEAE; CHEMICALS; ANALYTICAL chemistry
- Publication
Helvetica Chimica Acta, 2016, Vol 99, Issue 1, p83
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201500231